制药工程086002
邓先清
发布时间:2025-09-08 发布者:

基本信息

姓名

邓先清

职称

教授(博导)

E-mail

xqdeng@ybu.edu.cn

招生专业

生物与医药

研究方向

新药研发,抗菌,

抗癫痫,抗肿瘤药物先导物发现与优化

教育经历

起止时间

学习单位

学位

2007-2010

延边大学

药物化学硕士研究生

2010-2013

延边大学

药物化学硕士研究生




工作经历

起止时间

工作单位

职称

2013-2016

井冈山大学

讲师

2016-2021

井冈山大学

副教授

2019-2020

明尼苏达大学

访问学者

2021-现在

井冈山大学

教授

教学情况

本科生课程:药物化学》;《药学信息检索技术》

研究生课程:科研技能培养专题》

科研情况

主要研究领域包括神经精神疾病药物的先导物发现、优化及创新药物研发,中药资源与中成药的技术研究与开发等。近年来主持国家自然科学基金3项、江西省自然科学基金面上和青年项目多项,企业横向课题2项、参与科技部“重大新药创制”专项2项,参与国家自然科学基金项目3项,发表学术论文50余篇(一作/通讯),其中SCI收录40余篇,以第一发明人申请发明专利4项,其中授权3项;获江西省自然科学奖三等奖1项,吉林省自然科学奖二等奖、三等奖各1项。

学术兼职

1.江西省高等教育学会第四届理事会常务理事、江西省药学与中药学类专业教学指导委员会委员、美国化学会会员

2.江西省生物制品研究所、江西大自然药业、江西新赣江药业、江西复真药业等企业研发顾问

3.Frontiers in Chemistry》和《Molecules》客座编辑,《聊城大学学报》和《药学研究通报》编委

4.Frontiers in Chemistry, Arch. Pharm., Molecules, J. Enzym. Inhib. Med. Chem., Lett. Drug. Des. Disc., CNS. Neurol. Disord. Bioorg Med Chem Lett, Med Chem Res, Chemistry and Biodiversity, Lett. Drug. Des. Disc, Polycyclic Aromatic Compounds, Bioorg Chem, Med Chem, Scientific Reports等国际期刊同行评阅人。

科研项目

1.国家自然科学基金地区项目,22367014,靶向Myd88的同源聚合抑制剂的发现、优化及其抗癫痫作用研究,2024/01-2027/12,32万元,在研,主持

2.国家自然科学基金地区项目,22167017,基于分子杂合策略的H3R/GABAAR双靶点抗癫痫药物的设计、合成及活性研究,2022/01-2025/12,35万元,在研,主持

3.国家自然科学基金地区项目,21562028,癫痫合并抑郁症药物分子的设计、合成及药理活性研究,2016/01-2019/12,40万元,结题,主持

4.江西省杰出青年基金项目,基于H3R靶点的抗癫痫药物研发:Pitolisant衍生物的设计、合成及其抗癫痫活性与作用机制研究,2024/06-2027/05, 20242BAB23088,在研,主持

5.江西省自然科学基金项目,20202BABL206154,H3受体拮抗剂的设计、合成用于新型抗癫痫药物研究,2020/08-2022/12,6万元,结题,主持

6.江西省教育厅科技项目,GJJ211011,雷公藤红素衍生物的合成及其抗肿瘤活性和血管生成抑制活性研究,2021-2023,2022/01-2023/12,3万,结题,主持

7.江西省自然科学基金项目,20151BAB213008,以喹啉三唑为骨架的癫痫与抑郁共存症新药分子的结构修饰及活性评价,2015/04-2017/12,5万元,结题,主持

8.江西省自然科学基金项目,20142BAB215022,氨基脲衍生物的设计、合成及其抗癫痫活性研究,2014/08-2016/12,5万元,结题,主持

9.江西省教育厅科技计划项目,GJJ14570,SNRIsSARIs类抗抑郁药物的抗癫痫与致癫痫作用研究,2014/04-2017/03,1万元,结题,主持

10.吉安市科技局重点科技计划项目,20222-181833,基于H3R小分子抑制剂的抗癫痫药物研发,2022/12-2024/12,15万元,在研,主持

11.企业技术服务类项目,2021zkhx0002,正丁基硫代磷酸三胺的绿色合成工艺研究,2021/07-2023/6,10万元,结题,主持

12.企业技术服务类项目,2021zkhx0010,清热散结胶囊抗菌活性评价研究,2021/07-2023/7,2.5万元,结题,主持

13.科技部“重大新药创制” 专项,2012ZX09103-101-044,抗癫痫候选药物 W112的研究,2012/01-2014/12,150万,结题,参与

14.科技部“重大新药创制” 专项,2011ZX09102-003-03,抗癫痫一类新药-Q808胶囊的临床前研究,2011/01-2013/12,261万,结题,参与

个人荣誉与获奖

1. 江西省自然科学奖三等奖,排名第一,2022

2. 吉林省自然科学奖二等奖,排名第七,2011

3. 吉林省自然科学奖三等奖,排名第二,2016

4. 第五届本科院校全省高校青年教师教学竞赛二等奖,2022

5. 江西省教学成果奖二等奖,排名第三,2021

6. 井冈山大学“课程思政”优秀教学案例一等奖,2022

7. 井冈山大学2021年青年教师讲课比赛二等奖,2021

8. 江西省“双高”领军人才,2023

9. 江西省杰出青年基金获得者,2024

10. 井冈山大学“教书育人”先进个人,2021

11. 井冈山大学“庐陵之星”, 2019

代表性成果

[1] Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, Kyu-Yun Chai, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and Studies on Anticonvulsant and Antidepressant Activities of 5-Alkoxy-tetrazolo[1,5-a] quinolines. B KOREAN CHEM SOC,2010, 31(2):447.

[2] Xian-Qing Deng, Cheng-Xi Wei, Fu-Nan Li, Zhi-Gang Sun and Zhe-Shan Quan*.  Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivativeswith anticonvulsant activity. EUR J MED CHEM , 2010, 45(7):3080-6.

[3] Xian-Qing Deng, Cheng-Xi Wei, Ming-Xia Song, and Zhe-Shan Quan*. Synthesis and antidepressant-like action of 9-alkoxy-7H-furo[3,2-g]chromen-7-ones in mice.  ARZNEIMITTEL-FORSCH, 2010, 60(10):587-92.

[4] Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li, and Zhe-Shan Quan*. Synthesis and anticonvulsant activity of 7-alkoxy-triazolo-[3, 4-b]benzo[d]thiazoles. MED CHEM, 2010, 6(5):313-20.

[5] Xian-Qing Deng, Li-Na Quan, Cheng-Xi Wei, and Zhe-Shan Quan*.  Synthesis and anticonvulsant activity of 7-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-ones and their derivatives.  EUR J MED CHEM, 2011, 46:2955-63.

[6] Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Zhi-Gang Sun, Zhe-Shan Quan*. Synthesis and evaluation of 7-substituted-3,4-dihydrobenzo[b][1,4]oxazepin-5(2H)-ones as anticonvulsant and hypnotic agents. MED CHEM RES. 2011, 20 (7):996-1004.

[7] Xian-Qing Deng, Di Wu, Cheng-Xi Wei and Zhe-Shan Quan*. Synthesis and antidepressant-like action of N-(2-hydroxyethyl) cinnamamide derivatives in mice.  MED CHEM RES, 2011, 20 (8):1273-1279.

[8] Xian-Qing Deng, Chun-Rui Xiao, Cheng-Xi Wei, Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 5-Substituted-[1,2,4]triazolo[4,3-a]quinazolines. CHINESE J ORG CHEM, 2011, 31(12):2082.

[9] Xian-Qing Deng, zheng-Qi Dong, Ming-Xia Song, Bing Shu, Shi-Ben Wang, and Zhe-Shan Quan*. Synthesis and Anticonvulsant Activities of Some Triazolothiadiazole Derivatives. ARCH PHARM, 2012, 345: 565–573.

[10]. Xian-Qing Deng, Ming Xia Song, Shi-Ben Wang & Zheshan Quan*. Synthesis and evaluation of the anticonvulsant activity of 8-alkoxy-4,5-dihydrobenzo[b][1,2,4]triazolo[4,3-d][1,4]thiazepine derivatives. J Enzyme Inhib Med Chem, 2014, 29(2): 272-280.

[11] Xian-Qing Deng, Ming-Xia Song, Yan Zheng*, Zhe-Shan Quan*. Design, synthesis and evaluation of the antidepressant and anticonvulsant activities of triazole-containing quinolinones. EUR J MED CHEM, 2014, 73, 217-224.

[12] Xian-Qing Deng, Ming-Xia Song, Guo-Hua Gong, Shi-Ben Wang and Zhe-Shan Quan*. Synthesis and Anticonvulsant Evaluation of some New 6-(Substitutedphenyl)thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice. IRAN J PHARM RES, 2014, 13 (2): 459-469.

[13] Xian Qing Deng and Ming Xia Song*. Design and Synthesis of Pyrazolyl Thiosemicarbazones as New Anticonvulsants. Bull. Korean Chem. Soc. 2014, 35(9): 2733-7.

[14] Ming-Xia Song, Hong Zeng, Xian-Qing Deng*, Zhe-Shan Quan. Synthesis and Evaluation of Anticonvulsant Activities of Triazole-Incorporated Benzothiazoles. LETT DRUG DES DISCO, 2014, 11, 488-494.

[15] Xian-Qing Deng*, Ming-Xia Song, Bing Liu, Lin Xiao, Jia-Xing Zou, Tuan Li, Wen-Xing Chen, Li-Zhi Chen. Synthesis and Studies of 4-Phenylthiazol-2(3H)-one Derivatives as New Anticonvulsant Agents. Lat Am J Pharm 2014, 33 (9): 1430-5.

[16]. Ming-Xia Song, Yi Wu, Xian-Qing Deng*. Synthesis and Evaluation of Anticonvulsant Activities of Pyrazol yl Semicarbazones. Part II. LETT DRUG DES DISCO 2016, 13, (8): 800-808.

[17] Mingxia Song, Feng Xiao, Haihong Yu, Bing Liu & Xianqing Deng*. The Anticonvulsive Activities of Venlafaxine and its Interactions with Some Antiepileptic Drugs. Lat. Am. J. Pharm. 2016, 35(9): 1959-65.

[18] Yuede tan, Xiaoyan He, Baoqi Rao, Binbin Chen, Mingxia Song, Xianqing Deng*. Synthesis and Evaluation of the Anticonvulsant Activities of Triazole-Containing Benzo[d]oxazoles,Chin J Org Chem, 2016, 36, 2449-2455.

[19] Ming-Xia Song, Bao-Qi Rao, Bin-Bin Cheng, Yi, Wu, Hong Zeng, You-gen Luo and Xian-Qing Deng*. Design, Synthesis and Evaluation of the Antidepressant and Anticonvulsant Activities of Triazole-Containing Benzo[d]oxazoles. CNS & Neurological Disorders - Drug Targets, 2017, 16(2):187-198.

[20] Ming-Xia Song, Song-Hui Li, Jiao-Yang Peng, Ting-Ting Guo, Wen-Hui Xu, Shao-Feng Xiong and Xian-Qing Deng*. Synthesis and Bioactivity Evaluation of N-Arylsulfonylindole Analogs Bearing a Rhodanine Moiety as Antibacterial Agents. Molecules 2017, 22, 970.

[21] Ming-Xia Song and Xian-Qing Deng*. Recent developments on triazole nucleus in anticonvulsant compounds: a review. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2018, 33(1): 453-478.

[22] Ming-Xia Song, Zhen-Yuan Wang, Shi-Hui He, Sheng-Wang Yu, Shi-Long Chen, Dong-Fu Guo, Wen-Hao Zhao and Xian-Qing Deng*. Synthesis and Evaluation of the Anticonvulsant Activities of 4-(2-(Alkylthio)benzo[d]oxazol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-ones. Molecules 2018, 23, 756.

[23] Yi WU , Yu-ping HUANG , Sheng-Chao ZHOU , Yu-Qi TAN, Bao-Gui XU, Zhen LIANG & Xian-Qing DENG*. Synthesis of 1,3-Diaryl Pyrazole Derivatives and Evaluation of Anticonvulsant and Antimicrobial Activities. Lat. Am. J. Pharm. 2018, 37 (5): 1017-27.

[24] Ming-Xia SONG & Xian-Qing DENG*. Synthesis and Biological Evaluation of Uncharged Chalcone Derivatives as Novel PTP1B Inhibitors. Lat. Am. J. Pharm. 2018, 37 (1): 68-72.

[25] Yi Wu, Yuping Huang, Mingxia Song, Zongping Zhang, Zhen Liang and Xianqing Deng*. Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression. Pak. J. Pharm. Sci., 2019, 32(3): 997-1003.

[26] Zhaochang Liang, Yuping Huang, Shiben Wang and Xianqing Deng*. Synthesis and Biological Evaluation of Some Pyrazole Derivatives, Con- taining (Thio) Semicarbazide, as Dual Anti-Inflammatory Antimicrobial Agents. Letters in Drug Design & Discovery, 2019, 16, 1020-1030.

[27] Mingxia Song, Shiben Wang, Zengtao Wang, Zhiyang Fu, Shengchao Zhou, Huabin Cheng, Zhuo Liang, Xianqing Deng*. Synthesis, antimicrobial and cytotoxic activities, and molecular docking studies of N-arylsulfonylindoles containing an aminoguanidine, a semicarbazide, and a thiosemicarbazide moiety. European Journal of Medicinal Chemistry 166 (2019) 108-118.

[28] MingXia Song, Yuping Huang, XianQing Deng*. Design, synthesis, and evaluation of anticonvulsant activities of benzoxazole derivatives containing the 1,2,4‐triazolone moiety. Arch Pharm Chem Life Sci. 2019;352:1800313.

[29] Mingxia Song, Bing Liu, Shengwang Yu, Shihui He, Yuqiu Liang, Sifan Li, Qiuyan Chen and Xianqing Deng*. New Hydrazone Derivatives of Pyrazole-4-carboxaldehydes Exhibited Anti-inflammatory Properties. Letters in Drug Design & Discovery, 2020, 17, 502-511.

[30] Xianqing Deng & Mingxia Song*. Synthesis, antibacterial and anticancer activity, and docking study of aminoguanidines containing an alkynyl moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 354–364.

[31] Mingxia Song, Rui Yan, Yanhui Zhang, Dongfu Guo, Naiming Zhou* & XianQing Deng*. Design, synthesis, and anticonvulsant effects evaluation of nonimidazole histamine H3 receptor antagonists/inverse agonists containing triazole moiety. Journal of Enzyme Inhibition and Medicinal Chemistry 2020, 35(1), 1310–1321.

[32] Feng Xiao, Rui Yan, Yanhui Zhang, Naiming Zhou*, Xianqing Deng*. Synthesis and antiseizure effect evaluation of nonimidazole histamine H3 receptor antagonists containing the oxazole moiety. Arch Pharm. 2020, e2000298.

[33] Ming-Xia Song, Yu-Shan Huang, Qiu-Gui Zhou, Xian-Qing Deng*, Xiao-Dong Yao*. Synthesis of ring-opened derivatives of triazole-containing quinolinones and their antidepressant and anticonvulsant activities. Bioorg Chem, 2021, 106, 104505.

[34] Rui Yan, Xiaoliu Huang, Xianqing Deng* & Mingxia Song*. Synthesis and Activity Evaluation of Some Pyrazole–Pyrazoline Derivatives as Dual Anti- Inflammatory and Antimicrobial Agents. Polycyclic Aromatic Compounds. 2022, 42(8), 5006–5019.

[35] Song M, Zhao W, Zhu Y, Liu W, Deng X*, Huang Y*. Design, Synthesis, and Evaluation of Anticonvulsant Activities of New Triazolopyrimidine Derivatives. Front Chem. 2022, 10, 925281.

[36] Wenhao Luo, Wenli Liu, Yushan Huang and Xianqing Deng*.  Anticonvulsant and Proconvulsant Effects of Trazodone in Different Seizure Models. Int. J. Pharmacol., 2022, 18 (7): 1474-1481.

[37] Deng X, Sun H, Youssif BGM. Editorial: Pharmaceutical insights into the triazoles: Recent advances. Front Chem. 2023, 11, 1149133.

[38] Zhao W, Song M, Hua Y, Zhu Y, Liu W, Xia Q, Deng X*, Huang Y*. Design, Synthesis, and Pharmacology of New Triazole-Containing Quinolinones as CNS Active Agents. Molecules. 2023, 28(4) 1987.

[39] Hua Y, Song M, Guo Q, Luo Y, Deng X*, Huang Y*. Antiseizure Properties of Histamine H3 Receptor Antagonists Belonging 3,4-Dihydroquinolin-2(1H)-Ones. Molecules. 2023, 28(8), 3408.








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